SPHERE applies a multidisciplinary approach to breast cancer research. This includes mixed-method studies with an emphasis on big data and machine learning, real-world evidence, stratification of populations and patient engagement. A key goal of SPHERE's research is to understand how and why breast cancer affects different cohorts in different ways, such as women aged 40 and under or women aged 75 and older. Study results are used to identify, inform and create innovative strategies that will improve the quality, efficiency and outcomes of breast cancer care.
Reducing there Burden of Breast Cancer in Young Women
Co-PI: May Lynn Quan
Theme: Improving care for Canadians
A self-management intervention to support young women with breast cancer.
Sapphire: Improving Outcomes for Young Women with Breast Cancer
Co-PI: May Lynn Quan
Theme: Improving care for Canadians
A peer support app to support young women with and beyond breast cancer.
GeneScreen
PI: May Lynn Quan
Fellow: Cecily Stockley
Theme: Improving care for Albertans
NAC Pathway Project
Co-PI: Alison Laws
Student: Julia Downey
Theme: Improving care for Albertans
Surgical decision making in young breast cancer patients: Impact of pre-treatment surgical preference congruence with surgical treatment on psychosocial health.
PI: May Lynn Quan
Fellow: Melissa Wood
Theme: Improving care for Albertans
Diagnostic Delay Among Young Women with Breast Cancer
PI: May Lynn Quan
Resident: Katherine Fleshner
Theme: Improving care for Albertans
Young Women with Gene-negative Breast Cancer on Surgical Choice & Psychosocial Impacts
PI: May Lynn Quan
Resident: Christine Wang
Theme: Special population
Local Regional Management of the axilla in node-positive breast cancer patients following neo-adjuvant chemotherapy: an evaluation of real work practice
PI: May Lynn Quan
Resident: Katherine Fleschner
Theme: Special population
Prognostic significance of lobular versus ductal histology in HER2-positive breast cancer
PI: Alison Laws
Theme: Special population
Impact of Pre-operative MRI on Recurrence in Patients Diagnosed with Invasive Lobular Carcinoma
PI: Alison Laws
Fellow: Kadhim Taqi
Theme: Special population
Alert (Use of AI for ultrasounds)
PI: May Lynn Quan
Resident: Mary Hou
Theme: Evaluating/ using real-world data
Staging in T1-2N+ Breast cancer Project
PI: Alison Laws
Fellow: Kadhim Taqi
Theme: Improving care for Albertans
My Care: Timely, coordinated patient centered care for breast cancer patients treated with neo-adjuvant therapy.
PI: Alison Laws
Theme: Special population
Evaluating margins in Ductal Carcinoma In-Situ
PI: Alison Laws
Fellow/Residents: Mary Hou, Cecily Stockley, Meghan and Michelle (MS)
Theme: Special population
Targeted Axillary Surgery for Clinially Node-Positive Breast Cancer - retrospective
PI: Alison Laws
Resident: Emerik Arsenault
Theme: Special population
Targeted Axillary Surgery for Clinially Node-Positive Breast Cancery - prospective
PI: Alison Laws
Theme: Special population
Additional benefit of endocrine therapy to RT in postmenopausal patients with low-risk breast cancer
PI: Lisa Barbera
Theme: Special population
Breast feeding Post-BCT Project
PI: Lisa Barbera
Karishma George & Jade Pyo
Theme: Special population
PCR Project
PI: May Lynn Quan and Darren Brenner
Robert Basmadjian
Theme: Evaluating/ using real-world data
Reconstruction Radiation
PI: May Lynn Quan and Claire Temple-Oberle
Nina Samso
Theme: Improving care for Albertans
Re-Irradiation of Breast Cancer In-Field Recurrences: Locoregional Practice Patterns
PI: Natalie Logie and May Lynn Quan
Student: Conrad Bayley
Theme: Special population
Longitudinal Study of Psychosocial Outcomes Following Surgery in Women with Nonhereditary Breast Cancer
PI: May Lynn Quan & Kelly Metcalfe
Theme: Special population
Genetics Study
PI: May Lynn Quan & Kelly Metcalfe
Theme: Improving care for Albertans
Measuring and Characterizing Arm and Shoulder Dysfunction in Early Post-operative Breast Cancer Patients.
PI: Nathan Zondervan
Theme: Improving care for Albertans
Exploring patient factors influencing surgical treatment plan in young women with DCIS in Canada
PI: May Lynn Quan
Students: Karen Zeng & Asha Swamy
Theme: Special population
A Closer Look at Canadian Young Women 40 and Under with Primary Ductal Carcinoma in situ.
PI: May Lynn Quan
Students: Karen Zeng & Asha Swamy
Theme: Special population
MagSeed Evaluation (QI Project)
PI: May Lynn Quan and Alison Laws
Student: Ben Darby
Theme: Improving care for Albertans
Prevention of persistent pain with lidocaine infusions in breast cancer surgery (PLAN)
Exploring interventions to prevent persistent pain after breast cancer surgery through the use of lidocaine infusions.
Pilot Study to Establish Research Tools for Understanding the Biology of Breast Cancer in Women 40 Years and Under
PI: May Lynn Quan
Theme: Improving care for Albertans
A live cell banking process for young-onset breast tumours that can be used in live cell studies.
The Cancer Strategic Clinical Network (SCN) established the Provincial Breast Health Initiative to implement improvements and address gaps in care across breast cancer pathways.
PI: May Lynn Quan
Theme: Improving care for Albertans
Validating a natural language processing method for identifying complete pathologic response of breast cancer patients undergoing neoadjuvant chemotherapy from electronic pathology reports.
PI: Shawn Xu
Theme: Evaluating/ using real-world data
New methods to determine the diagnostic interval for cancer patients using administrative data.
PI: Shawn Xu
Theme: Evaluating/ using real-world data
Developing algorithms to determine the cancer patients with metastatic recurrence using real-world data.
PI: Shawn Xu
Theme: Evaluating/ using real-world data
A Prediction Model for Pathologic Complete Response Following Neoadjuvant Chemotherapy in Breast Cancer Using Routinely-collected Health Record Data in Alberta
PI: Darren Brenner
Theme: Evaluating/ using real-world data
Prediction models to support successful neoadjuvant treatment.
Mutational Landscape Differences Between Young-Onset and Older-Onset Breast Cancer Patients
PI: Darren Brenner
Theme: Evaluating/ using real-world data
A cross-comparison of tumours that will help identify mutational signatures by age group.
SPHERE | Strategies for Precision Health in Breast Cancer
University of Calgary
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