SPHERE applies a multidisciplinary approach to breast cancer research. This includes mixed-method studies with an emphasis on big data and machine learning, real-world evidence, stratification of populations and patient engagement. A key goal of SPHERE's research is to understand how and why breast cancer affects different cohorts in different ways, such as women aged 40 and under or women aged 75 and older. Study results are used to identify, inform and create innovative strategies that will improve the quality, efficiency and outcomes of breast cancer care.
Reducing there Burden of Breast Cancer in Young Women
Co-PI: May Lynn Quan
A self-management intervention to support young women with breast cancer.
Sapphire: Improving Outcomes for Young Women with Breast Cancer
Co-PI: May Lynn Quan
A self-management intervention to support young women with breast cancer.
IN-SYNC: A Pilot Study to Establish Research Tools for Understanding the Biology of Breast Cancer in Women 40 Years and Under
PI: May Lynn Quan
A live cell banking process for young-onset breast tumours that can be used in live cell studies.
A Prediction Model for Pathologic Complete Response Following Neoadjuvant Chemotherapy in Breast Cancer Using Routinely-collected Health Record Data in Alberta
PI: Darren Brenner
Prediction models to support successful neoadjuvant treatment.
Mutational Landscape Differences Between Young-Onset and Older-Onset Breast Cancer Patients
PI: Darren Brenner
A cross-comparison of tumours that will help identify mutational signatures by age group.
The Cancer Strategic Clinical Network (SCN) established the Provincial Breast Health Initiative to implement improvements and address gaps in care across breast cancer pathways.
PI: May Lynn Quan
Validating a natural language processing method for identifying complete pathologic response of breast cancer patients undergoing neoadjuvant chemotherapy from electronic pathology reports.
PI: Shawn Xu
New methods to determine the diagnostic interval for cancer patients using administrative data.
PI: Shawn Xu
Developing algorithms to determine the cancer patients with metastatic recurrence using real-world data.
PI: Shawn Xu
Prevention of persistent pain with lidocaine infusions in breast cancer surgery (PLAN)
Exploring interventions to prevent persistent pain after breast cancer surgery through the use of lidocaine infusions.
Melissa Wood, Kelly Metcalfe, Yuan Xu, Susan Isherwood, Xing Wang, Yue Yang, May Lynn Quan, & the RUBY Site Investigators. Surgical Decision Making in Young Breast Cancer Patients: Impact of Pre-treatment Surgical Preference Congruence with Final Surgical Treatment on Psychosocial Health. Poster presentation at the Canadian Breast Cancer Symposium in Toronto June 2023.
Explore projects by our General Surgery Residents and their contributions to SPHERE:
Christine Wang, Melissa Wood, Yuan Xu, Flora Yang, Susan Isherwood, MayLynn Quan. Surgical Decision Making and Psychosocial Outcomes in Young Gene Mutation Carriers with Breast Cancer- The Patients Perspective. Poster Presented at the Canadian Cancer Research Alliance Conference, November 11-14 2023; Halifax, Nova Scotia
Katherine Fleschner, Yuan Xu, Susan Isherwood, Emily Hanniman, Antoine Bouchard-Fortier, May Lynn Quan. Local Regional Management of the axilla in node-positive breast cancer patients following neo-adjuvant chemotherapy: an evaluation of real work practice. Poster presentation at American Society of Breast Surgeons, Las Vegas April 2022.
Steven Langer, Shiying Kong, Yuan Xu, May Lynn Quan. Investigating factors associated with post-mastectomy emergency department visits: a population based analysis. Poster presentation at American Society of Breast Surgeons, Las Vegas April 2022.
Steven Langer, Yuan Xu, Shiying Kong, Jennifer Puddy, May Lynn Quan. Investigating Factors Associated with Postmastectomy Emergency Department Visits: A Population-Based Analysis. Ann Surg Oncol. 2023 Jul 15. doi: 10.1245/s10434-023-13727-6. Epub ahead of print. PMID: 37454012. Read
Improving CARE in Elderly Breast Cancer Patients A retrospective study that identifies strategies to improve treatment and outcomes for women aged 75 and older.
SPHERE | Strategies for Precision Health in Breast Cancer
University of Calgary
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